Litcius/Paper detail

Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors

Zijie Cai, Jingru Wang, Yudong Li, Qianfeng Shi, Liang Jin, Shunying Li, Mengdi Zhu, Qi Wang, Lok Lam Wong, Yang Wang, Hongna Lai, Chang Gong, Yandan Yao, Yujie Liu, Jun Zhang, Herui Yao, Qiang Liu

2022Science China Life Sciences106 citationsDOI

Topics & Concepts

PalbociclibCyclin D1Cancer researchPI3K/AKT/mTOR pathwayCyclin-dependent kinase 4Cyclin DCyclin A2Cell cycleCyclin-dependent kinaseBreast cancerBiologyChemistryCancerCyclin-dependent kinase 2Cell biologySignal transductionMetastatic breast cancerGeneticsAdvanced Breast Cancer TherapiesCancer-related Molecular PathwaysChronic Lymphocytic Leukemia Research
Overexpressed Cyclin D1 and CDK4 proteins are responsible for the resistance to CDK4/6 inhibitor in breast cancer that can be reversed by PI3K/mTOR inhibitors | Litcius