Next-Generation Sequencing in Oncology—A Guiding Compass for Targeted Therapy and Emerging Applications
Laurenţia Galeş, Mihai-Andrei Păun, Ioana Butnariu, Laurentiu Simion, Loredana Sabina Cornelia Manolescu, Oana Trifănescu, Rodica Maricela Anghel
Abstract
Multigene sequencing technologies provide a foundation for targeted therapy and precision oncology by identifying actionable alterations and enabling the development of treatments that substantially improve clinical outcomes. This review emphasizes the importance of having a molecular compass guiding treatment decision-making through the multitude of alterations and genetic mutations, showcasing why NGS plays a pivotal role in modern oncology.
Topics & Concepts
Precision oncologyCompassPrecision medicineTargeted therapyMedicineComputational biologyDNA sequencingGenomic sequencingBioinformaticsOncologyInternal medicineBiologyCancerPathologyGeneticsGeneGenomeGeographyCartographyCancer Genomics and DiagnosticsProtein Degradation and InhibitorsLung Cancer Treatments and Mutations