Sesquiterpenoid-Chromone Heterohybrids from Agarwood of <i>Aquilaria sinensis</i> as Potent Specific Smad3 Phosphorylation Inhibitors
Xiaoling Huang, Ye‐Ting Zhou, Yong‐Ming Yan, Yong‐Xian Cheng
Abstract
could significantly inhibit the expression of extracellular matrix components, and α-SMA at low concentrations in TGF-β1 induced two types of kidney cells (NRK 52E and NRK 49F) featuring selective inhibition of Smad3 instead of Smad2 phosphorylation, showing their potential in renal fibrosis.
Topics & Concepts
ChromoneAgarwoodChemistryPhosphorylationBiochemistryTraditional medicineStereochemistryMedicineAlternative medicinePathologyWood and Agarwood ResearchMicrobial Metabolism and ApplicationsCultural Heritage Materials Analysis