Multi-Omics Analysis Reveals the Protection of Gasdermin D in Concanavalin A-Induced Autoimmune Hepatitis
Kaicen Wang, Wenrui Wu, Xianwan Jiang, Jiafeng Xia, Longxian Lv, Shengjie Li, Aoxiang Zhuge, Zhengjie Wu, Qiangqiang Wang, Shuting Wang, Lanjuan Li
Abstract
mice. This finding suggested a nonnegligible role of GSDMD in AIH and also confirmed its physiological nonpyroptosis effects on the host. The role of GSDMD in autoimmune liver diseases or other liver diseases is complex and intriguing, deserving deep investigation.
Topics & Concepts
Concanavalin APyroptosisInflammationAutoimmune hepatitisBiologyLiver injuryTumor necrosis factor alphaCD14ImmunologyHepatitisEndocrinologyBiochemistryInflammasomeImmune systemIn vitroInflammasome and immune disordersLiver Diseases and ImmunityIL-33, ST2, and ILC Pathways