Aerobic exercise training reduces ET-1-mediated vasoconstriction and improves endothelium-dependent vasodilation in postmenopausal women
Megan M. Wenner, Laura M. Welti, Caitlin A. Dow, Jared J. Greiner, Brian L. Stauffer, Christopher A. DeSouza
Abstract
Endothelin-1 (ET-1) contributes to declines in endothelial function in postmenopausal women. To our knowledge, we show for the first time that aerobic exercise reduces ET-1-mediated vasoconstriction in previously sedentary postmenopausal women. Moreover, aerobic exercise improved endothelial-dependent dilation due in part to the reductions in ET-1-mediated vasoconstriction.
Topics & Concepts
VasoconstrictionAerobic exerciseVasodilationPostmenopausal womenEndotheliumMedicineInternal medicineEndothelin 1Endothelin receptorCardiologyEndocrinologyReceptorCardiovascular Health and Disease PreventionBlood Pressure and Hypertension StudiesCardiovascular and exercise physiology