Mechanisms of the “No-Reflow” Phenomenon After Acute Myocardial Infarction
Sanjiv Kaul, Carmen Methner, Zhiping Cao, Anusha Mishra
Abstract
Pericytes contract during myocardial ischemia resulting in capillary constriction and no reflow. Reversing pericyte contraction pharmacologically reduces no reflow and infarct size. These findings open up an entire new venue of research aimed at altering pericyte function in myocardial ischemia and infarction.
Topics & Concepts
PericyteCardiologyMyocardial infarctionNo reflow phenomenonInternal medicineMedicineIschemiaInfarctionContraction (grammar)Endothelial stem cellChemistryConventional PCIIn vitroBiochemistryUltrasound and Hyperthermia ApplicationsCardiac electrophysiology and arrhythmiasAdvanced MRI Techniques and Applications