Green-synthesized gold nanoparticles from black tea extract enhance the chemosensitivity of doxorubicin in HCT116 cells <i>via</i> a ROS-dependent pathway
Tanushree Das, Snehasis Mishra, Sayoni Nag, Krishna Das Saha
Abstract
a ROS-dependent pathway by enhancing the pro-apoptotic protein expression. Therefore, our results indicated that green gold nanoparticles of black tea extract (BTE-GNP) may be potent chemosensitizers of doxorubicin.
Topics & Concepts
DoxorubicinCytotoxicityApoptosisFlow cytometryChemistryColloidal goldMTT assayWestern blotCytotoxic T cellConfocal microscopyBlotCell cultureMolecular biologyBiophysicsNanoparticleIn vitroBiochemistryMaterials scienceBiologyCell biologyNanotechnologyChemotherapyGeneticsGeneTea Polyphenols and EffectsCell death mechanisms and regulationTannin, Tannase and Anticancer Activities