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Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors

Tianxiao Wu, Chu Zhang, Ruicheng Lv, Qiaohua Qin, Nian Liu, Wenbo Yin, Ruifeng Wang, Yin Sun, Xiaoyan Wang, Yixiang Sun, Dongmei Zhao, Maosheng Cheng

2021European Journal of Medicinal Chemistry23 citationsDOIOpen Access PDF

Topics & Concepts

PharmacophoreTrk receptorChemistryADMEDrug discoveryKinaseStructure–activity relationshipPharmacologyReceptorStereochemistryBiochemistryIn vitroBiologyNeurotrophinMelanoma and MAPK PathwaysCytokine Signaling Pathways and InteractionsSignaling Pathways in Disease
Design, synthesis, biological evaluation and pharmacophore model analysis of novel tetrahydropyrrolo[3,4-c]pyrazol derivatives as potential TRKs inhibitors | Litcius