Copper-Catalyzed Aminosulfonylation of <i>O</i>-Homoallyl Benzimidates with Sodium Sulfinates to Access Sulfonylated 1,3-Oxazines
Wei Dong, Zhuo‐Yue Fang, Tong-Yang Cao, Jie-Hui Cao, Ziqiang Zhao, Linlin Zhang, Wei Li, Qi Lin, Lijin Wang
Abstract
A facile copper-catalyzed aminosulfonylation of O-homoallyl benzimidates with sodium sulfinates in the presence of tert-butyl peroxybenzoate (TBPB) and XPhos ligand has been developed. By using this protocol, a variety of potentially bioactive 1,3-oxazines were directly synthesized. This method has the merits of a cheap catalyst, easily available and stable sulfone reagents, and simple operation.
Topics & Concepts
ChemistryOxazinesCatalysisReagentSodiumCopperCombinatorial chemistryLigand (biochemistry)Organic chemistryBiochemistryReceptorSulfur-Based Synthesis TechniquesSynthesis and Catalytic ReactionsCatalytic C–H Functionalization Methods