STING couples with PI3K to regulate actin reorganization during BCR activation
Yukai Jing, Xin Dai, Lu Yang, Danqing Kang, Panpan Jiang, Na Li, Jiali Cheng, Jingwen Li, Heather Miller, Boxu Ren, Quan Gong, Wei Yin, Zheng Liu, Pieta K. Mattila, Qin Ning, Jinqiao Sun, Bing Yu, Chaohong Liu
Abstract
KO B cells upon BCR stimulation. Mechanistically, STING uses PI3K mediated by the CD19-Btk axis as a central hub for controlling the actin remodeling that, in turn, offers feedback to BCR signaling. Overall, our study provides a mechanism of how STING regulates BCR signaling via feedback from actin reorganization, which contributes to positive regulation of STING on the humoral immune response.
Topics & Concepts
StingCell biologybreakpoint cluster regionActinPI3K/AKT/mTOR pathwayChemistryBiologySignal transductionGeneticsPhysicsGeneThermodynamicsinterferon and immune responsesMosquito-borne diseases and controlUbiquitin and proteasome pathways