Association between vitamin D supplementation and cancer incidence and mortality: A trial sequential meta-analysis of randomized controlled trials
Zhangyou Guo, Ming Huang, Dandan Fan, Hong Yuan, Min Zhao, Rong Ding, Yao Cheng, Shigang Duan
Abstract
= 0%). Moreover, trial sequential analysis provided reliable evidence that supplementation with vitamin D lowered the relative risk of total cancer mortality by 10%. Our updated meta-analysis suggested that vitamin D supplementation did not reduce total cancer incidence but significantly lowered total cancer mortality.Supplemental data for this article is available online at https://doi.org/10.1080/10408398.2022.2056574 .
Topics & Concepts
MedicineMeta-analysisInternal medicineIncidence (geometry)Randomized controlled trialPlaceboRelative riskCancerVitamin D and neurologyObservational studyVitaminClinical trialConfidence intervalPathologyPhysicsAlternative medicineOpticsVitamin D Research StudiesVitamin C and Antioxidants ResearchBone health and osteoporosis research