Binge alcohol disrupts skeletal muscle core molecular clock independent of glucocorticoids
Abigail L. Tice, Joseph A. Laudato, Michael L. Rossetti, Christopher A. Wolff, Karyn A. Esser, Choogon Lee, Charles H. Lang, Cynthia Vied, Bradley S. Gordon, Jennifer L. Steiner
Abstract
Alcohol is a myotoxin that impairs skeletal muscle metabolism and function following either chronic consumption or acute binge drinking; however, mechanisms underlying alcohol-related myotoxicity have not been fully elucidated. Herein, we demonstrate that alcohol acutely interrupts oscillation of skeletal muscle core clock genes, and this is neither a direct effect of ethanol on the skeletal muscle, nor an effect of elevated serum corticosterone, a major clock regulator.
Topics & Concepts
PER1EndocrinologyInternal medicineCLOCKCircadian rhythmCorticosteroneCircadian clockZeitgeberPER2MyogenesisBiologySkeletal muscleMedicineHormoneCircadian rhythm and melatoninExercise and Physiological ResponsesSpaceflight effects on biology