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Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders

Han Gao, Jiawei Di, Bettina Hjelm Clausen, Nanxiang Wang, Xizhong Zhu, Tianlun Zhao, Yanyu Chang, Mao Pang, Yang Yang, Ronghan He, Yuge Wang, Liangming Zhang, Bin Liu, Wei Qiu, Kate Lykke Lambertsen, Roberta Brambilla, Limin Rong

2023Cell Reports14 citationsDOIOpen Access PDF

Abstract

(Cell Reports 42, 112629; June 27, 2023) In the originally published version of this article, Han Gao, the first author of this paper, was given the position of corresponding author as well as lead contact due to a misunderstanding regarding these roles. After an explanation of the roles were given, the three original corresponding authors (Han Gao, Roberta Brambilla, and Limin Rong) agreed that corresponding author duties should be limited to Brambilla and Rong. Furthermore, the position of lead contact should be given to Limin Rong, who is designated as corresponding author and has accepted responsibility of handling communications about the paper from readers. The article has since been updated to reflect the accurate responsibilities of each author. The authors regret this error and any confusion that it may have caused. Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disordersGao et al.Cell ReportsJune 7, 2023In BriefGao et al. identify the existence of two distinct phenotypes of microglia and infiltrating myeloid cells dependent on TREM2 expression levels at the acute stage of spinal cord injury (SCI) and experimental autoimmune encephalomyelitis (EAE), and the authors elucidate how they mediate the opposing effects of TREM2 in the two disorder models. Full-Text PDF Open Access

Topics & Concepts

TREM2PhenotypeConfusionMicrogliaPopulationMyeloidImmunologyNeuroscienceExpression (computer science)MedicineExperimental autoimmune encephalomyelitisPsychologyMultiple sclerosisPathologyBiologyInflammationPsychoanalysisGeneticsGeneEnvironmental healthProgramming languageComputer scienceInflammation biomarkers and pathwaysNeuroinflammation and Neurodegeneration MechanismsNeurological Disease Mechanisms and Treatments
Distinct myeloid population phenotypes dependent on TREM2 expression levels shape the pathology of traumatic versus demyelinating CNS disorders | Litcius