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Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis

Kexin Hu, Qing Zhang, Yang Chen, Jintong Yang, Ying Xia, Bing Rao, Shaobai Li, Yafeng Shen, Cao Mi, Hongliang Lu, An Qin, Xian‐Cheng Jiang, Deqiang Yao, Jie Zhao, Lu Zhou, Yu Cao

2024Nature Structural & Molecular Biology23 citationsDOI

Topics & Concepts

SphingomyelinCeramideCeramide synthaseSphingolipidDiacylglycerol kinaseATP synthaseBiochemistrySphingomyelin phosphodiesteraseBiosynthesisChemistryCell biologySphingosineLipid signalingBiologySignal transductionEnzymeMembraneReceptorProtein kinase CApoptosisSphingolipid Metabolism and SignalingLipid Membrane Structure and BehaviorErythrocyte Function and Pathophysiology
Cryo-EM structure of human sphingomyelin synthase and its mechanistic implications for sphingomyelin synthesis | Litcius