Augmenting TCR signal strength and ICOS costimulation results in metabolically fit and therapeutically potent human CAR Th17 cells
Megan M. Wyatt, Logan W. Huff, Michelle H. Nelson, Lillian R. Neal, Andrew Medvec, Guillermo O. Rangel Rivera, Aubrey S. Smith, Amalia M. Rivera Reyes, Hannah M. Knochelmann, James L. Riley, Gregory B. Lesinski, Chrystal M. Paulos
Topics & Concepts
T-cell receptorSignal strengthCell biologyChemistryT cellImmunologyBiologyMolecular biologyCancer researchComputer scienceImmune systemTelecommunicationsWirelessCAR-T cell therapy researchImmunotherapy and Immune ResponsesImmune Cell Function and Interaction