The emerging role of RNA N6-methyladenosine methylation in breast cancer
Fangchao Zheng, Feng Du, Jiuda Zhao, Xue Wang, Yiran Si, Jin Peng, Haili Qian, Binghe Xu, Peng Yuan
Abstract
N6-methyladenosine (m6A) modification is the most prevalent internal mRNA modification and is involved in many biological processes in eukaryotes. Accumulating evidence has demonstrated that m6A may play either a promoting or suppressing role in breast cancer, including in tumorigenesis, metastasis and angiogenesis. In this review, we summarize the latest research progress on the biological function and prognostic value of m6A modification in breast cancer, as well as potential related therapeutic strategies.
Topics & Concepts
N6-MethyladenosineBreast cancerRNA methylationCarcinogenesisMethylationAngiogenesisDNA methylationMedicineMetastasisRNABioinformaticsCancer researchCancerOncologyInternal medicineBiologyMethyltransferaseDNAGeneGene expressionGeneticsRNA modifications and cancerCancer-related gene regulationCancer-related molecular mechanisms research