Cationic Nanoparticle-Mediated Activation of Natural Killer Cells for Effective Cancer Immunotherapy
Kwang-Soo Kim, Jun‐Hyeok Han, Seung Hee Choi, Hae‐Yun Jung, Joo Dong Park, Hee Jung An, Seong Eun Kim, Dong‐Hyun Kim, Junsang Doh, Dong Keun Han, Ik-Hwan Kim, Wooram Park, Kyung‐Soon Park
Abstract
by magnetic resonance imaging. Thus, cNP-mediated activation of NK cells has great potential as an NK cell-based cancer immunotherapy. Most of all, activating NK cells using cNPs has a great advantage over conventional methods in that immune cells can be activated by a one-step facile process with exogenously charged nanomaterials, without the need for genetic engineering or cytokine treatment.
Topics & Concepts
Interleukin 12Cancer cellCancer immunotherapyCytotoxic T cellImmunotherapyCancer researchInterleukin 21CytokineImmune systemMaterials scienceChemokineCancerBiologyCell biologyImmunologyIn vitroT cellBiochemistryGeneticsImmune Cell Function and InteractionImmunotherapy and Immune ResponsesCAR-T cell therapy research