Fast X-ray ptychography: towards nanoscale imaging of large volume of brain
Silvia Cipiccia, Michela Fratini, Ecem Erin, Marco Palombo, Silvia Vogel, Max Burian, Fenglei Zhou, Geoff J.M. Parker, Darren Batey
Abstract
Abstract X-ray ptychography, a scanning coherent diffraction imaging technique, is one of the most used techniques at synchrotron facilities for high resolution imaging, with applications spanning from life science to nano-electronics. In the recent years there has been a great effort to make the technique faster to enable high throughput nanoscale imaging. Here we apply a fast ptychography scanning method to image in 3D $$10^6\upmu \mathrm{{m}}^3$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:mrow> <mml:msup> <mml:mn>10</mml:mn> <mml:mn>6</mml:mn> </mml:msup> <mml:mi>μ</mml:mi> <mml:msup> <mml:mrow> <mml:mi>m</mml:mi> </mml:mrow> <mml:mn>3</mml:mn> </mml:msup> </mml:mrow> </mml:math> of brain-like phantom at 3 kHz, in a 7 h acquisition with a resolution of 270 nm. We then present the latest advances in fast ptychography by showing 2D images acquired at 110 kHz by combining the fast-acquisition scheme with a high-acquisition rate prototype detector from DECTRIS Ltd. We finally review the experimental outcome and discuss the prospective use of fast ptychography schemes for the investigation of mm $$^{3}$$ <mml:math xmlns:mml="http://www.w3.org/1998/Math/MathML"> <mml:msup> <mml:mrow/> <mml:mn>3</mml:mn> </mml:msup> </mml:math> size samples of brain-like phantom, by extrapolating the current results to the high coherent flux scenario of diffraction limited storage rings.