Optimal synthesis conditions for NBF-modified 8,13-dihydroberberine derivatives
Alexander D. Zagrebaev, Vera V. Butova, Alexander A. Guda, Sergei V. Chapek, Олег Н. Буров, С. В. Курбатов, E. Yu. Vinyukova, Маргарита Е. Неганова, Yulia Aleksandrova, Н. С. Николаева, Олег П. Демидов, А. В. Солдатов
Abstract
We developed a microfluidic synthesis with UV-Vis diagnostics using a 3D printed chip for 8,13-disubstituted berberines. This system yielded up to 30% higher product yields with high antioxidant activity compared to traditional batch synthesis.
Topics & Concepts
ChemistryMicrofluidic chipCombinatorial chemistryMicrofluidicsChipProduct (mathematics)NanotechnologyEngineeringMathematicsElectrical engineeringMaterials scienceGeometryBerberine and alkaloids researchChemical synthesis and alkaloidsAlkaloids: synthesis and pharmacology