Intraepidermal Merkel Cell Carcinoma Mimicking Melanoma in Situ: A Case Report
Yali Song, Song Zheng, Ying Guo
Abstract
Merkel cell carcinoma (MCC) is an uncommon, but aggressive neoplasm with neuroendocrine differentiation that occurs on sun-damaged skin of the elderly. Because its clinical presentation is usually nonspecific, the diagnosis is often made after histopathologic evaluation. Most cases are intradermal. Epidermal involvement is uncommon, whereas MCC limited to the epidermis is extremely rare. Here, we describe a case of MCC in an 88-year-old man with an extraordinary histopathologic presentation, namely nested intraepidermal proliferation of neoplastic cells highly resembling melanoma in situ.
Topics & Concepts
Merkel cell carcinomaMerkel cellPathologyMelanomaEpidermis (zoology)NeoplasmPresentation (obstetrics)MedicineDermatologyCarcinomaAnatomyCancer researchRadiologyPolyomavirus and related diseasesFull-Duplex Wireless CommunicationsAntenna Design and Analysis