Recent advances in the development of EGFR degraders: PROTACs and LYTACs
Dawei Hong, Bizhong Zhou, Bei Zhang, Hao Ren, Liquan Zhu, Guowan Zheng, Minghua Ge, Jingyan Ge
Topics & Concepts
Epidermal growth factor receptorChemistryEGFR inhibitorsTransmembrane proteinTyrosine kinaseReceptor tyrosine kinaseCancer researchComputational biologyReceptorBiologyBiochemistryProtein Degradation and InhibitorsPeptidase Inhibition and AnalysisCancer therapeutics and mechanisms