Inhibition of the proline metabolism rate-limiting enzyme P5CS allows proliferation of glutamine-restricted cancer cells
Samantha J Linder, Tiziano Bernasocchi, Bárbara Martínez-Pastor, Kelly D. Sullivan, Matthew D. Galbraith, Caroline A. Lewis, Christina M. Ferrer, Ruben Boon, Giórgia Gobbi da Silveira, Hyo Min Cho, Charles Vidoudez, Stuti G. Shroff, João Paulo Oliveira–Costa, Kenneth N. Ross, Rami Massri, Yusuke Matoba, Eugene Kim, Bo R. Rueda, Shannon L. Stott, Eyal Gottlieb, Joaquı́n M. Espinosa, Raúl Mostoslavsky
Topics & Concepts
GlutamineProlineCell growthCancer cellDownregulation and upregulationBiochemistryMetabolismBiologyBiosynthesisGlutaminolysisMetaboliteMetabolic pathwayEnzymeAmino acidCancerGeneGeneticsCancer, Hypoxia, and MetabolismCancer-related Molecular PathwaysEpigenetics and DNA Methylation