CHOP is dispensable for exercise-induced increases in GDF15
Logan K. Townsend, Kyle D. Medak, Alyssa J. Weber, Hana A. Dibe, Hesham Shamshoum, David C. Wright
Abstract
GDF15 is expressed in a wide range of tissues, is a marker of cellular stress, and has been shown to be regulated by the ER stress protein CHOP. Although exercise increases GDF15, the mechanisms mediating this effect have not been elucidated. Using various models of altered ER stress, we demonstrate that exercise-induced increases in GDF15 occur independent of ER stress/CHOP.
Topics & Concepts
GDF15CHOPUnfolded protein responseEndocrinologyInternal medicineEndoplasmic reticulumBiologyMedicineCell biologyGDF15 and Related BiomarkersNutrition and Health in AgingGenetics and Neurodevelopmental Disorders