Alginate Alleviates Dextran Sulfate Sodium-Induced Colitis by Promoting Bifidobacterium animalis and Intestinal Hyodeoxycholic Acid Synthesis in Mice
Yu Pi, Xiangyu Zhang, Yujun Wu, Zhenyu Wang, Yu Bai, Xiaoyi Liu, Dandan Han, Jinbiao Zhao, Isabel Tobin, Jiangchao Zhao, Guolong Zhang, Junjun Wang
Abstract
and secondary BA (HDCA), ALG contributed to the attenuation of DSS-induced colitis. These findings contribute to a better understanding of the mechanism of action of ALG on the attenuation of colitis and provide new approaches to IBD therapy by regulating gut microbial BA metabolism.
Topics & Concepts
ColitisBifidobacterium animalisDysbiosisInflammatory bowel diseaseMicrobiologyFarnesoid X receptorChemistryDownregulation and upregulationProinflammatory cytokineBifidobacteriumInflammationGut floraBiologyImmunologyBiochemistryInternal medicineMedicineLactobacillusNuclear receptorGeneDiseaseFermentationTranscription factorGut microbiota and healthHelicobacter pylori-related gastroenterology studiesGastrointestinal motility and disorders