Biophysical insights into the binding capability of Cu(II) schiff base complex with BSA protein and cytotoxicity studies against SiHa
Minakshi Maity, Ushasi Pramanik, Venkatesha R. Hathwar, Paula Brandão, Saptarshi Mukherjee, Swapan Maity, Ribhu Maity, Tithi Maity, Bidhan Chandra Samanta
Abstract
anti-proliferative potentiality against SiHa cell. The complex was synthesized involving a Schiff base ligand having N,N,O donor centers and characterized by several spectroscopic studies. Structure, DFT studies and Hirshfeld surface (HS) analyses were identified using crystallographic computational studies. The binding interaction with BSA depicts the efficacy of the complex towards promising binding of it with BSA. Further, the complex shows a moderate cytotoxicity against SiHa cancer cell signifying its potentiality as an anti-proliferative agent for human cervix uteri carcinoma.
Topics & Concepts
CytotoxicityBovine serum albuminChemistrySchiff baseLigand (biochemistry)In vitroBinding siteBiochemistryStereochemistryMolecular biologyBiologyReceptorMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsProtein Interaction Studies and Fluorescence Analysis