Hepatitis B reactivation following switch away from tenofovir-containing anti-retroviral therapy in people living with HIV: A case series and lessons for practice
Flora Olcott, Philip D Oddie, Maeve J Barlow, Athanasios Mamarelis, Matthew Byott, Paul R. Grant, Johannes C. Botha, Clare Booth, Laura Waters, Philippa C. Matthews, Stuart Flanagan, Eleni Nastouli, Indrajit Ghosh
Abstract
The potential for hepatitis B reactivation must be considered when switching people with HIV and prior hepatitis B exposure away from tenofovir-containing combined anti-retroviral therapy. Four cases of hepatitis B reactivation from the United Kingdom are presented. Hepatitis B mutations, risk factors and pre- and post-switch recommendations are explored.
Topics & Concepts
MedicineHepatitis BHepatitis B virusVirologyHuman immunodeficiency virus (HIV)HepatitisImmunologyHepatitis CViral diseaseOrthohepadnavirusFamily medicineAcute hepatitis BHepadnaviridaePediatricsIntensive care medicineRisk factorHepatitis APublic healthViral hepatitisEpidemiologyHepatitis B Virus StudiesHIV/AIDS drug development and treatmentHepatitis C virus research