The Identification of Potent, Selective, and Brain Penetrant PI5P4Kγ Inhibitors as In Vivo-Ready Tool Molecules
Timothy P. C. Rooney, Gregory G. Aldred, Helen K. Boffey, Henriëtte M. G. Willems, Simon Edwards, Stephen J. Chawner, Duncan E. Scott, Christopher Green, David Winpenny, John Skidmore, Jonathan H. Clarke, Stephen P. Andrews
Abstract
) in complex with PI5P4Kγ, along with its selectivity data against >150 kinases and a Cerep safety panel.
Topics & Concepts
ChemistryKinaseDrug discoverySmall moleculeIn vivoPenetrant (biochemical)PharmacophoreNeurodegenerationIn silicoComputational biologyVirtual screeningPhenotypic screeningPharmacologyADMEBiochemistryIn vitroBiologyPhenotypeGeneMedicineBiotechnologyPathologyDiseaseOrganic chemistryChronic Lymphocytic Leukemia ResearchCellular transport and secretionBiochemical and Molecular Research