Irradiation of Bifunctional Masked Ketone Pro-Aromatics Unveils Autoinductive Autocatalysis via Electron Donor–Acceptor (EDA) Complexes
Cheng-Lin Chan, Yong‐Ting Tsao, Aira Shayne Paculba, Pei-Shan Lin, Zong‐Nan Tsai, Hung-Hsuan Chiu, Risa Kunitake, Ming-Jia Chiu, Chun-Chi Yeh, Cheng‐chau Chiu, Hsuan‐Hung Liao
Abstract
We disclose an autocatalytic electron donor-acceptor (EDA) strategy by reutilizing redox auxiliary byproducts as in situ acceptors, enabling an external initiator-free activation of pro-aromatic dihydroquinazolinones (DHQZs). Spectroscopic and DFT data support the Lewis acid-enhanced aggregate formation where DHQZ serves as both donor and latent acceptor through its quinazolinone byproduct. Kinetic studies reveal a kinetic profile specifically representing autoinductive autocatalysis. This platform enables Giese-type acylation/alkylation, desulfonylation, and Minisci reactions, forging C-C, C-N, C-S, and C-Se bonds under mild conditions.