Brain capillary pericytes are metabolic sentinels that control blood flow through a KATP channel-dependent energy switch
Ashwini Hariharan, Colin D. Robertson, Daniela C.G. Garcia, Thomas A. Longden
Abstract
-mediated pericyte hyperpolarization to increase local blood flow. Together, our findings recast capillary pericytes as metabolic sentinels that respond to local energy deficits by increasing blood flow to neurons to prevent energetic shortfalls.
Topics & Concepts
PericyteArterioleHyperpolarization (physics)Blood flowCell biologyPotassium channelChemistryNeuroscienceBiologyBiophysicsInternal medicineMicrocirculationEndothelial stem cellBiochemistryMedicineIn vitroNuclear magnetic resonance spectroscopyOrganic chemistryBarrier Structure and Function StudiesErythrocyte Function and PathophysiologyNeuroscience and Neuropharmacology Research