Dual pH-sensitive nanodrug blocks PD-1 immune checkpoint and uses T cells to deliver NF-κB inhibitor for antitumor immunotherapy
Zecong Xiao, Zhenwei Su, Shisong Han, Jinsheng Huang, Liteng Lin, Xintao Shuai
Abstract
T cells may be released in the tumor microenvironment, leaving aPD-1 to block PD-1 on T cells and generating a CUR-encapsulated cationic nanodrug that can be easily taken up by tumor cells/tumor associated macrophages (TAMs). Thus, not only the antitumor T cells mediate efficient CUR delivery to tumor but also the efficient CUR delivery promotes the tumor infiltration of antitumor T cells, thereby resulting in effective activation of antitumor immunity.
Topics & Concepts
ImmunotherapyImmune systemCancer researchDual (grammatical number)Immune checkpointCancer immunotherapyChemistryMedicineImmunologyArtLiteratureNanoplatforms for cancer theranosticsCancer Immunotherapy and BiomarkersImmunotherapy and Immune Responses