Rolling circle amplification-driven encoding of different fluorescent molecules for simultaneous detection of multiple DNA repair enzymes at the single-molecule level
Chen-chen Li, Huiyan Chen, Juan Hu, Chun‐yang Zhang
Abstract
for UDG. It can be further applied for simultaneous detection of multiple DNA glycosylases in cancer cells at the single-cell level and the screening of DNA glycosylase inhibitors, holding great potential in early clinical diagnosis and drug discovery.
Topics & Concepts
Rolling circle replicationDNAFluorescenceEncoding (memory)MoleculeEnzymeBiophysicsChemistryComputational biologyCombinatorial chemistryNanotechnologyMaterials scienceBiologyBiochemistryPhysicsDNA polymeraseOpticsNeuroscienceOrganic chemistryAdvanced biosensing and bioanalysis techniquesDNA and Nucleic Acid ChemistryDNA Repair Mechanisms