Highly electrophilic silver carbenes
Xiaolong Zhang, Linxuan Li, Paramasivam Sivaguru, Giuseppe Zanoni, Xihe Bi
Abstract
)-C(O) insertion, cycloaddition, and defluorinative functionalization. The silver-catalyzed carbene transfer reactions described here have high efficiency, unusual reactivity, exceptional selectivity, and a reaction pathway that differs from typical transition metal-catalyzed reactions. Our research provided fundamental insight into silver carbene chemistry, and we hope to apply this mode of catalysis to other more general transformations, including asymmetric transformations.
Topics & Concepts
CarbeneElectrophileDiazoChemistryCatalysisCombinatorial chemistryReactivity (psychology)Transition metal carbene complexCycloadditionPhotochemistryOrganic chemistryAlternative medicinePathologyMedicineCyclopropane Reaction MechanismsCatalytic C–H Functionalization MethodsSynthesis and Catalytic Reactions