Optogenetic activation of cortical microglia promotes neuronal activity and pain hypersensitivity
Min‐Hee Yi, Yi Liu, Yong Liu, Jinkyung Lee, Priyanka Hanumaihgari, Sebastian Parusel, Dale B. Bosco, Lingxiao Wang, Jiaying Zheng, Shi Wu, Lattawat Eauchai, Supin Chompoopong, Christine Hunt, Long‐Jun Wu
Abstract
Yi et al. demonstrate that optogenetic activation of cortical microglia in the primary somatosensory cortex (S1) induces pain hypersensitivity and affective pain responses in mice. This process involves microglial landscape changes, ATP release, and enhanced neuronal activity, providing mechanistic insight into the role of cortical microglia in chronic pain.
Topics & Concepts
OptogeneticsMicrogliaNeurosciencePremovement neuronal activitySomatosensory systemMedicineBiologyImmunologyInflammationVagus Nerve Stimulation ResearchPhotoreceptor and optogenetics researchAnesthesia and Neurotoxicity Research