Biochemical and structural characterization of<i>Haemophilus influenzae</i>nitroreductase in metabolizing nitroimidazoles
Dake Liu, Thisuri N. Wanniarachchi, Guangde Jiang, Gustavo Seabra, Shugeng Cao, Steven D. Bruner, Yousong Ding
Abstract
mutant strain to 5-nitroimidazoles under anaerobic conditions. Together, these results advance our understanding of the metabolism of nitroimidazole antibiotics mediated by a new NTR group and reinforce the research on the natural antibiotic resistome for addressing the antibiotic resistance crisis.
Topics & Concepts
NitroreductaseNitroimidazoleChemistryHaemophilus influenzaeAntibioticsAntibiotic resistanceMicrobiologyDrug resistanceEnzymeAntimicrobialBiochemistryBiologyOrganic chemistryAntibiotic Resistance in BacteriaCancer therapeutics and mechanismsBacterial Genetics and Biotechnology