Molecular Profiling Reveals a Common Metabolic Signature of Tissue Fibrosis
Ji Zhang, Eric S. Muise, Seongah Han, Peter S. Kutchukian, Philippe Costet, Yonghua Zhu, Yanqing Kan, Haihong Zhou, Vinit Shah, Yongcheng Huang, Ashmita Saigal, Taro E. Akiyama, Xiaolan Shen, Tian‐Quan Cai, Kashmira Shah, Ester Carballo‐Jane, Emanuel Zycband, Lan Yi, Ye Tian, Ying Chen, Jason E. Imbriglio, Elizabeth Smith, Kristine Devito, James Conway, Li‐Jun Ma, Maarten Hoek, Iyassu K. Sebhat, Andrea Peier, Saswata Talukdar, David G. McLaren, Stephen F. Previs, Kristian Jensen, Shirly Pinto
Abstract
. Altogether, our work demonstrate that metabolic defect is integral to TGF-β signaling and fibrosis.
Topics & Concepts
FibrosisTranscriptomePhenotypeIn vivoDownregulation and upregulationExtracellular matrixBiologyCancer researchAMPKCell biologyPathologyMedicineGeneGene expressionGeneticsPhosphorylationProtein kinase ALiver Disease Diagnosis and TreatmentLiver physiology and pathologyChronic Kidney Disease and Diabetes