PERK inhibition attenuates vascular remodeling in pulmonary arterial hypertension caused by <i>BMPR2</i> mutation
Takashi Shimizu, Yoshiki Higashijima, Yasuharu Kanki, Ryo Nakaki, Takeshi Kawamura, Yoshihiro Urade, Youichiro Wada
Abstract
Inhibiting the PERK arm of the unfolded protein response may alleviate pulmonary arterial hypertension.
Topics & Concepts
BMPR2Pulmonary hypertensionMutationMedicineCardiologyInternal medicineVascular remodelling in the embryoBiologyGeneticsGeneBone morphogenetic proteinPulmonary Hypertension Research and TreatmentsATP Synthase and ATPases ResearchCardiovascular Function and Risk Factors