SHMT inhibition is effective and synergizes with methotrexate in T-cell acute lymphoblastic leukemia
Juan Carlos García‐Cañaveras, Olga Lancho, Gregory S. Ducker, Jonathan M. Ghergurovich, Xincheng Xu, Victoria da Silva-Diz, Sonia Minuzzo, Stefano Indraccolo, Hahn Kim, Daniel Herranz, Joshua D. Rabinowitz
Topics & Concepts
Serine hydroxymethyltransferaseMethotrexateIn vivoSerineDihydrofolate reductaseAntifolateBiologyLeukemiaCancer researchAcute lymphocytic leukemiaBiochemistryEnzymePharmacologyAntimetaboliteImmunologyLymphoblastic LeukemiaBiotechnologyAcute Lymphoblastic Leukemia researchChildhood Cancer Survivors' Quality of LifeEpigenetics and DNA Methylation