Csx3 is a cyclic oligonucleotide phosphodiesterase associated with type III CRISPR–Cas that degrades the second messenger cA4
Sharidan Brown, Colin C. Gauvin, Alexander A. Charbonneau, Nathaniel Burman, C. Martin Lawrence
Abstract
signal, providing an off ramp from the programmed cell death pathway in cells that successfully cure viral infection.
Topics & Concepts
Second messenger systemNucleaseCRISPROligonucleotideChemistryRNACell biologyBiologyGeneBiochemistrySignal transductionCRISPR and Genetic EngineeringAdvanced biosensing and bioanalysis techniquesRNA and protein synthesis mechanisms