Hyaluronan Degradation by Cemip Regulates Host Defense against Staphylococcus aureus Skin Infection
Tatsuya Dokoshi, Ling-juan Zhang, Fengwu Li, Teruaki Nakatsuji, Anna M. Butcher, Hiroyuki Yoshida, Masayuki Shimoda, Yasunori Okada, Richard L. Gallo
Abstract
mice challenged with S. aureus also had greater IL-6 expression and neutrophil infiltration. These observations describe a mechanism for hyaluronan in the dermal ECM to regulate tissue inflammation and host antimicrobial defense.
Topics & Concepts
Staphylococcus aureusDermisCathelicidinHyaluronic acidMicrobiologyAntimicrobial peptidesExtracellular matrixLipoteichoic acidInflammationHyaluronan synthaseBiologyCatabolismAntimicrobialImmunologyCell biologyBacteriaBiochemistryEnzymeGeneticsAnatomyProteoglycans and glycosaminoglycans researchImmune Response and InflammationCell Adhesion Molecules Research