The osteogenic response to chirality-patterned surface potential distribution of CFO/P(VDF-TrFE) membranes
Jiamin Zhang, Xuzhao He, Zhiyuan Zhou, Xiaoyi Chen, Jiaqi Shao, Donghua Huang, Lingqing Dong, Jun Lin, Huiming Wang, Wenjian Weng, Kui Cheng
Abstract
, which significantly up-regulates the Arp2/3 complex expression, a crucial factor for cytoskeleton reorganization, possibly increases cytoskeleton contractility, and strengthens the transduction of the osteogenesis-related signaling cascade. This work proves that the chirality-patterns in surface potential distributions could provide an osteogenic response similar to a chirality-patterned topological surface.
Topics & Concepts
Chirality (physics)Sinistral and dextralMembraneMesenchymal stem cellFocal adhesionMaterials scienceCell biologyChemistryBiophysicsNanotechnologyTopology (electrical circuits)Signal transductionBiologyPhysicsBiochemistryQuarkPaleontologyChiral symmetry breakingCombinatoricsQuantum mechanicsMathematicsNambu–Jona-Lasinio modelTectonicsCellular Mechanics and InteractionsPlanarian Biology and ElectrostimulationBone Tissue Engineering Materials