A honokiol-mediated robust coating for blood-contacting devices with anti-inflammatory, antibacterial and antithrombotic properties
Linhua Li, Chong Chen, Chunle Zhang, Rifang Luo, Xiaorong Lan, Fan Guo, Liang Ma, Ping Fu, Yunbing Wang
Abstract
reached 99.98% and 99.99%, respectively. In addition, subcutaneous implantation indicated that the DPHc coating also has excellent histocompatibility. To the best of our knowledge, this is the first study using HK as a coating material that can not only combat thrombosis and infection but also significantly inhibit inflammation associated with the use of blood-contacting materials, thus expanding the application of HK in the field of biomaterials.
Topics & Concepts
HonokiolAntithromboticCoatingMaterials scienceNanotechnologyMedicinePharmacologyInternal medicineMagnolia and Illicium researchOxidative Organic Chemistry ReactionsPharmacological Effects of Natural Compounds