Extracellular flux analyses reveal differences in mitochondrial PBMC metabolism between high-fit and low-fit females
Joëlle J. E. Janssen, Bart Lagerwaard, Mojtaba Porbahaie, Arie G. Nieuwenhuizen, Huub F. J. Savelkoul, R. J. Joost van Neerven, Jaap Keijer, Vincent C. J. de Boer
Abstract
Mitochondrial metabolism was significantly higher in PBMCs from high-fit than from low-fit females. This was unrelated to PBMC composition and not impacted by a recent bout of exercise. Our study reveals a link between PBMC metabolism and levels of aerobic fitness, increasing the relevance of PBMC metabolism as a marker to study the impact of lifestyle factors on human health.
Topics & Concepts
Peripheral blood mononuclear cellBasal metabolic rateInternal medicineMetabolismEndocrinologyExtracellularGlycolysisBiologyMedicineChemistryAndrologyImmunologyBiochemistryIn vitroAdipose Tissue and MetabolismMuscle metabolism and nutritionDiet and metabolism studies