Coumarin–benzimidazole hybrids: Design, synthesis and identification of potential anticancer agents
C. G. Arya, Neethu Mariam Thomas, Munugala Chandrakanth, Anoop Kallingal, P.G. Amrutha, Mrs. J Sivapriya, Ramesh Gondru, Janardhan Banothu
Topics & Concepts
ChemistryCytotoxicityIn silicoConjugateIn vitroA549 cellCell cultureDocking (animal)Structure–activity relationshipBiological activityBiochemistryStereochemistryADMECancer cellKinaseDoxorubicinSphingosine kinase 1PharmacologyPotencyMolecular modelLead compoundPharmacophoreLipinski's rule of fiveDrugSphingosineCombinatorial chemistryCrizotinibIn vitro toxicologyIn vivoChemical synthesisQuinazolineDrug discoveryCell growthMCF-7Synthesis and biological activitySynthesis and Biological EvaluationSynthesis of Organic Compounds