Association Between Obstructive Sleep Apnea, Its Treatment, and Alzheimer's Disease: Systematic Mini-Review
Chih-Yun Kuo, Hung‐Ta Hsiao, Ing-Hsien Lo, Tomáš Nikolai
Abstract
Obstructive sleep apnea (OSA) and Alzheimer's disease (AD) are common in the elderly population. Obstructive sleep apnea that may cause significant changes in the cerebrospinal fluid β-amyloid and T-tau and/or P-tau protein levels is often identified as a risk factor for development of AD. Although the underlying mechanisms of AD are still not fully understood, a hypothesis associating OSA with AD has been already proposed. In this systematic mini-review, we first discuss the recent findings supporting the association of OSA with an increased risk of AD and then provide evidence suggesting the positive effect of OSA treatment on a reduced risk of AD.
Topics & Concepts
Obstructive sleep apneaMedicineDiseaseSleep apneaRisk factorAlzheimer's diseaseSleep (system call)PopulationInternal medicineBioinformaticsNeurosciencePsychologyBiologyOperating systemComputer scienceEnvironmental healthObstructive Sleep Apnea ResearchNeuroscience of respiration and sleepDysphagia Assessment and Management