CD4+ T cells drive an inflammatory, TNF-α/IFN-rich tumor microenvironment responsive to chemotherapy
Caitlin M. Tilsed, Nicola Principe, Joel Kidman, Wee Loong Chin, M. Lizeth Orozco Morales, Rachael M. Zemek, Jonathan Chee, Rasa Islam, Vanessa S. Fear, Catherine A. Forbes, Wayne J. Aston, Maud H.E. Jansen, Abha Chopra, Timo Lassmann, Anna K. Nowak, Scott Fisher, Richard Lake, W. Joost Lesterhuis
Abstract
T cell-inflamed pre-treatment tumor microenvironment is necessary for response to chemotherapy, and this state can be therapeutically attained by targeted immunotherapy.
Topics & Concepts
Tumor microenvironmentCyclophosphamideChemotherapyTumor necrosis factor alphaCancer researchImmunotherapyImmune systemMedicineImmunologyBiologyInternal medicineCancer Immunotherapy and BiomarkersImmunotherapy and Immune ResponsesImmune cells in cancer