FUNDC1 alleviates doxorubicin-induced cardiotoxicity by restoring mitochondrial-endoplasmic reticulum contacts and blocked autophagic flux
Weibin He, Zhongchan Sun, Guang Tong, Lin Zeng, Wenlong He, Xiaopan Chen, Cien Zhen, Pengyuan Chen, Ning Tan, Pengcheng He
Abstract
: In summary, our study identified that FUNDC1-meditated MERCs exerted a cardioprotective effect against DIC by restoring the blocked autophagosome biogenesis. Importantly, this research reveals a novel role of FUNDC1 in enhancing macroautophagy via restoring MERCs structure and autophagosome biogenesis in the DIC model, beyond its previously known regulatory role as an mitophagy receptor.
Topics & Concepts
Endoplasmic reticulumAutophagyCardiotoxicityDoxorubicinFlux (metallurgy)MitochondrionCell biologyChemistryMedicinePharmacologyCancer researchApoptosisInternal medicineBiologyBiochemistryChemotherapyOrganic chemistryMitochondrial Function and PathologyChemotherapy-induced cardiotoxicity and mitigationCalcium signaling and nucleotide metabolism