Molecular characterisation of mutations associated with resistance to first- and second-line drugs among Indonesian patients with tuberculosis
Faiqah Umar, Dirayah Rauf Husain, Mochammad Hatta, Rosdiana Natzir, Rizalinda Sjahril, Ressy Dwiyanti, Ade Rifka Junita, Muhammad Reza Primaguna
Abstract
OBJECTIVES: isolated from a cohort of Indonesian patients with tuberculosis. METHODS: . RESULTS: gene (S95T, D94V, A90V, and S91P) including the pan-susceptible strain. CONCLUSIONS: genes. Molecular characterisation using DNA sequencing techniques is a highly sensitive approach for detecting mutations.
Topics & Concepts
rpoBMycobacterium tuberculosisCapreomycinRifampicinIsoniazidTuberculosisBiologyGeneticsGene mutationMutationStreptomycinGeneDrug resistanceVirologyMicrobiologyMedicineAntibioticsEthambutolPathology16S ribosomal RNATuberculosis Research and EpidemiologyMycobacterium research and diagnosisDiagnosis and treatment of tuberculosis