Adjusting for common variant polygenic scores improves yield in rare variant association analyses
Sean J. Jurgens, James P. Pirruccello, Seung Hoan Choi, Valerie N. Morrill, Mark Chaffin, Steven A. Lubitz, Kathryn L. Lunetta, Patrick T. Ellinor
Topics & Concepts
BiologyGeneticsAssociation (psychology)Genetic associationGenome-wide association studyComputational biologyStatisticsSingle-nucleotide polymorphismGenotypeGeneMathematicsEpistemologyPhilosophyGenetic Associations and EpidemiologyGenomics and Rare DiseasesGenetic Mapping and Diversity in Plants and Animals