RNA Methylation m<sup>6</sup>A: A New Code and Drug Target?
Gan‐Qiang Lai, Linlin Zhou, Cai‐Guang Yang
Abstract
The m 6 A‐RNA modification is a dynamic and reversible process, which has emerged as a new RNA code for the regulation of gene expression. The functional network of methyltransferases (writers), demethylases (erasers), and binding proteins (readers) modulate the level of m 6 A modification. Dysfunction of RNA methylation has been associated with various fundamental biological processes and human diseases. Herein, we briefly introduce an understanding‐enabled manipulation on m 6 A‐RNA modification with an emphasis on the use of small‐molecule intervention.
Topics & Concepts
MethyltransferaseRNAChemistryRNA methylationMethylationComputational biologyNon-coding RNAGene expressionGenetic codeGeneBiochemistryBiologyRNA modifications and cancerCancer-related gene regulationRNA and protein synthesis mechanisms