Interferon β drives intestinal regeneration after radiation
Brian J. Leibowitz, Guangyi Zhao, Wei Liang, Hang Ruan, Michael W. Epperly, Lujia Chen, Xinghua Lu, Joel S. Greenberger, Lin Zhang, Jian Yu
Abstract
stem cell regeneration through elevated compensatory proliferation and more rapid DNA damage removal. Our findings support that inducible IFN-β production in the niche couples ISC injury and regeneration and its potential use to treat acute radiation injury.
Topics & Concepts
Regeneration (biology)InflammationCell biologyStem cellRadiation injuryBiologyInterferonImmunologyIntestinal epitheliumEpitheliumMedicineNeurosciencePathologyRadiation therapyInternal medicineEffects of Radiation ExposureCancer Cells and MetastasisHydrogen's biological and therapeutic effects